CBD and its Relation with CB1 and CB2 Receptors and the Endocannabinoid System

After extraction and processing, a pure form of CBD oil is obtained from the resin glands of the flower of Cannabis Sativa plant. This CBD oil is mixed with Carriers like olive oil coconut oil all flavors essential oils so that a good CBD product is produced. However, all manufacturers have to keep in mind that all authentic CBD products should not contain more than 0.3 % THC.

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The Cannabis sativa plant has several cannabinoids. One of them is cannabidiol and there is a relationship between CBD and the human brain.

The DEA has classified cannabinoids as a schedule 1 controlled substance which is similar to LSD and heroin. Cannabinoids are active chemicals that bind together with ECS receptors located in a body.  According to scientists, human brain creates its cannabinoids through the ECS which is responsible for functions like sleep movement emotion and appetite, pain, stress, response, appetite, and memory.

Cannabinoids activate two types of receptors –

  • CB1 receptors found in the central nervous system which controls the brain and nerve endings.
  • CB2 receptors, found in the immune system.

The THC component found in the Cannabis plant binds with the CB1 receptor and leaves psychoactive effects on the brain.  On the other hand, CBD has a major effect on receptors. It doesn’t mind with cb1 receptors as strongly as THC does. This means, it doesn’t block the receptors and doesn’t provide psychoactive effects.

On consumption of CBD, the receptors are affected and some parts of the brain get involved. This varies from person to person depending upon various other factors like age, genes, other medication and amount of CBD consumed.

CBD’s Effect on Brain

Reduces blood flow

A study was done on people who were suffering from social anxiety disorder (SAD). According to the research, people suffering from SAD felt better after consuming CBD. It relaxed and calm the brain reducing anxiety and stress. After scanning their brain, it was revealed that there were changes in blood flow in the area that were connected to anxiety.

Pain management

CBD also affects CB1 and CB2 receptors differently.  These receptors respond differently to pain signals which help in reducing pain and inflammation. CBD is known to have anti-inflammatory property, which helps in pain management.


Cells present in our body generate energy along with free radicals as waste products. Even environmental toxins create free radicals in our bodies. Sometimes, free radicals are excessive in quantity due to which antioxidants created in our body are unable to stabilize the waste and this waste starts killing our DNA particles. This results in atherosclerosis, Parkinson’s, and Alzheimer’s. CBD contains antioxidant property which acts with CB2 receptors to decrease the damage of free radicals.

However, over dosage of CBD can also produce adverse effects on a human being, because most trials are done on rats and mice. Thus, always consult a doctor before using CBD first time.